If you do as Jason suggested and put in an one-way-valve, so you end up with a negative pressure inside the Crankcase - then all is good, as you wont get any leakage + you reduce the pumping losses.
My (old) full size engines have approx. Ø12mm. hole for the breather - for 550-1100cc. - the nevest I believe is Ø16mm. for 650cc.
Per